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dnadesign sequence toolkit

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dnadesign is a modular bioinformatics toolkit for designing sequence libraries, assembling DNA constructs, running sequence models, and analyzing the resulting datasets.


Documentation

Use the docs index to choose a workflow, inspect existing work, or jump to a tool.


Available tools

Pick the tool that matches the work you need to do. Each link opens the tool README for commands, inputs, and outputs.

Design, modeling, and analysis

Tool Description
usr Store, check, and sync tables of sequence records.
densegen Generate DNA sequence libraries from saved design inputs.
infer Run sequence models and add their predictions to datasets.
construct Build DNA constructs from reusable templates.
msd Resolve and compile typed Retron MSD designs.
junction Turn exact DNA targets into checked three-way-junction oligo plans.
opal Use measured results to choose which DNA designs to test next.
cluster Group similar rows and visualize the groups.
latentdna Compare sequence features and save tables and plots for review.
cruncher Design DNA sequences and assembly plans within stated limits.
billboard Measure how much binding-site content varies across a sequence library.
libshuffle Choose smaller, representative sets from large sequence libraries.
nmf Find motif patterns that repeatedly occur together in a data table.
permuter Create sequence variants and evaluate them with selected tools.
tfkdanalysis Summarize experiments that reduce selected transcription factors.
aligner Compare pairs or sets of DNA and protein sequences.
thread Prepare protein-design jobs and check the predicted structures.

Draw and inspect results

Tool Description
folding Predict and draw how RNA sequences fold.
baserender Draw annotated sequence maps from saved jobs.

Run and monitor jobs

Tool Description
ops Find, run, and inspect jobs across dnadesign.
notify Send notifications for local and scheduled jobs.

Data shared between tools

Tool Description
contracts Define versioned file formats shared between tools.

About

A collection of bioinformatic modules and data analysis pipelines, all related to DNA sequence design.

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