diff --git a/CHANGELOG.md b/CHANGELOG.md
index 4c462112a7..5c18d040ad 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -116,6 +116,9 @@ Increment the:
 * [CONFIGURATION] Apply default sampler when none is specified
   [#4170](https://github.com/open-telemetry/opentelemetry-cpp/pull/4170)
 
+* [BAZEL] Upgrade grpc and protobuf dependencies
+  [#4164](https://github.com/open-telemetry/opentelemetry-cpp/pull/4164)
+
 ## [1.27.0] 2026-05-13
 
 * [RELEASE] Bump main branch to 1.27.0-dev
diff --git a/MODULE.bazel b/MODULE.bazel
index 07e443a3c3..4ad117755f 100644
--- a/MODULE.bazel
+++ b/MODULE.bazel
@@ -11,13 +11,13 @@ module(
 bazel_dep(name = "abseil-cpp", version = "20260107.1", repo_name = "com_google_absl")
 bazel_dep(name = "bazel_skylib", version = "1.9.0")
 bazel_dep(name = "curl", version = "8.12.0.bcr.1")
-bazel_dep(name = "grpc", version = "1.80.0", repo_name = "com_github_grpc_grpc")
+bazel_dep(name = "grpc", version = "1.81.1", repo_name = "com_github_grpc_grpc")
 bazel_dep(name = "nlohmann_json", version = "3.12.0.bcr.1", repo_name = "github_nlohmann_json")
 bazel_dep(name = "opentelemetry-proto", version = "1.8.0", repo_name = "com_github_opentelemetry_proto")
 bazel_dep(name = "opentracing-cpp", version = "1.6.0", repo_name = "com_github_opentracing")
 bazel_dep(name = "platforms", version = "1.1.0")
 bazel_dep(name = "prometheus-cpp", version = "1.3.0.bcr.2", repo_name = "com_github_jupp0r_prometheus_cpp")
-bazel_dep(name = "protobuf", version = "32.0", repo_name = "com_google_protobuf")
+bazel_dep(name = "protobuf", version = "33.6", repo_name = "com_google_protobuf")
 bazel_dep(name = "rapidyaml", version = "0.12.1")
 bazel_dep(name = "rules_cc", version = "0.2.20")
 bazel_dep(name = "rules_foreign_cc", version = "0.15.1")